Fecal Calprotectin Test

Fecal calprotectin is a specialized stool test that measures the level of calprotectin — a protein released by white blood cells (neutrophils) when there is inflammation in the intestines. It is the single most useful non-invasive marker for intestinal inflammation, particularly in Crohn's disease and ulcerative colitis (IBD). It can also help differentiate IBD from IBS (irritable bowel syndrome), which does not cause inflammation.

Calprotectin is essential for: diagnosing IBD (Crohn's disease and ulcerative colitis) without needing a colonoscopy as a first step; monitoring IBD disease activity and treatment response; detecting IBD flares early before symptoms worsen; distinguishing IBD from IBS (which has normal calprotectin); and deciding when a colonoscopy is truly needed. Normal levels (<50 µg/g) strongly suggest no significant inflammation, while elevated levels (>200 µg/g) indicate active intestinal inflammation.

1. You receive a stool collection kit to take home
2. Collect a small stool sample (about the size of a walnut) using the kit
3. Place it in the labeled container and seal it
4. Return to the laboratory (ideally the same day)
5. Results are typically available within 2–5 days

5 minutes collection + 2–5 days for results

• ✓No fasting required
• ✓No dietary restrictions
• ✓Avoid NSAIDs (ibuprofen, aspirin) for 2 weeks before the test if possible, as they can raise calprotectin levels
• ✓Collect the sample and return it to the lab as soon as possible

• •Simple stool sample collection at home — completely private
• •No pain, no preparation, no dietary changes needed
• •Your doctor will explain the results in context of your symptoms
• •May be repeated periodically to monitor IBD treatment effectiveness
• •A high result does not automatically mean IBD — your doctor will guide next steps